Evaluating the Effectiveness of Aqueous Extract of Persian Oak (Quercus castaneifolia C.A.Mey.) Fruit Hull on Dermal Wound Healing in the Rat Model

Background: Persian oak (Quercus castaneifolia C.A.Mey) belongs to the Fagaceae family. This plant is commonly used in Iranian traditional medicine treat inflammatory and gastric ulcers. Objectives: study aimed assess efficacy of fruit aqueous hull extract on wound healing rats. Methods: Thirty-five male Wistar rats were randomly divided into five groups, then two full-thickness wounds 10 mm diameter created bilaterally back animals. The negative control group received saline, positive was treated with phenytoin cream, three treatment groups 2%, 4%, 8% Jaft extract. animals these medicines once daily for 15 days. percentage evaluated using contraction ratio, re-epithelialization, tensile strength, vascular endothelial growth factor (VEGF), platelet-derived (PDGF) content. Histopathological examination performed repaired tissues. Results: In closure rate significantly higher than saline group. revealed significant improvement (P < 0.05) compared contraction, epithelialization duration, VEGF, PDGF plasma level. investigations also exhibited development Conclusions: shows that effective animal models. Clinical trials are required prove Q. spray various humans.